产品货号：
Z38061
中文名称：
FEN1抗体
英文名称：
Anti-FEN1 Antibody (Clone#7D11D7)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FEN1 Antibody (Clone#7D11D7) |
| 指标别名 | DNase IV;FEN 1;FEN1;Flap endonuclease 1;flap structure endonuclease 1;hFEN 1;Maturation factor 1;MF1;RAD2 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | FEN1 |
| 克隆号 | 7D11D7 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | E.coli-derived human FEN1 recombinant protein (Position:Q4-E300). |
| 实际分子量 | 48KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | protein G purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.It is mapped to 11q12.2.The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis.Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate,thus passing the substrate from one enzyme to another.The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication.DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene.Therefore,secondary structure can deter the protective function of this protein,leading to site-specific trinucleotide expansions. |
| Uniprot ID | P39748 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Mouse IgG (ZN1928) for Western blot,and HRP Conjugated anti-Mouse IgG Super Vision Assay Kit (ZN1866) for IHC(P) and ICC. |
| 基因名全称 | flap structure-specific endonuclease 1 |
| 蛋白名全称 | Flap endonuclease 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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